New Trends in Pharmacological Treatments for Osteoarthritis

Osteoarthritis (OA) is the leading cause of function loss and disability among elderly, with significant burden on individual society. It a severe disease for its high rates, morbidity, costs, increased mortality. Multifactorial etiologies contribute to occurrence development OA. The heterogeneous condition poses challenge effective treatment OA; however, emerging treatments are promising bring benefits OA management in future. This narrative review will discuss recent developments agents OA, including potential disease-modifying osteoarthritis drugs (DMOADs) novel therapeutics pain relief. focus more that have been clinical trials, as well attractive applications preclinical research. In past few years, it has realized complex interaction multifactorial mechanisms involved pathophysiology authors believe there no miracle therapeutic strategy fitting all patients. phenotyping would be helpful therapy selection. A variety targeting inflammation mechanisms, cellular senescence, cartilage metabolism, subchondral bone remodeling, peripheral nociceptive pathways expected reshape landscape over next years. Precise randomized controlled trials (RCTs) identify safety efficacy therapies specific patients phenotypes.